EC number 3.5.1.78 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 171040-71-4 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a glutathionylspermidine amidase (EC 3.5.1.78) is an enzyme that catalyzes the chemical reaction
glutathionylspermidine + H2OThus, the two substrates of this enzyme are glutathionylspermidine and H2O, whereas its two products are glutathione and spermidine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase. This enzyme is also called glutathionylspermidine amidohydrolase (spermidine-forming). This enzyme participates in glutathione metabolism.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2IO7, 2IO8, 2IO9, 2IOA, and 2IOB.