Glucosylceramidase

Updated on Dec 12, 2024

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EC number 3.2.1.45 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 37228-64-1 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a glucosylceramidase (EC 3.2.1.45) is an enzyme that catalyzes the chemical reaction

D-glucosyl-N-acylsphingosine + H₂O ⇌ D-glucose + N-acylsphingosine

Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H₂O, whereas its two products are D-glucose and N-acylsphingosine.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include:

psychosine hydrolase,

glucosphingosine glucosylhydrolase,

GlcCer-beta-glucosidase,

beta-D-glucocerebrosidase,

glucosylcerebrosidase,

beta-glucosylceramidase,

ceramide glucosidase,

glucocerebrosidase,

glucosylsphingosine beta-glucosidase,

and glucosylsphingosine beta-D-glucosidase.

This enzyme participates in sphingolipid metabolism and degradation of glycan structures.

Human proteins containing this domain

GBA belongs to Glycoside hydrolase family 30 , GBA2 belongs to Glycoside hydrolase family 116.

References

Glucosylceramidase Wikipedia

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