Species Human Entrez 57704 | Human Mouse Ensembl ENSG00000070610 | |
Aliases GBA2, SPG46, AD035, NLGase, glucosylceramidase beta 2 External IDs MGI: 2654325 HomoloGene: 10859 GeneCards: GBA2 | ||
GBA2 is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans. It has glucosylceramidase (EC 3.2.1.45) activity.
Function
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
References
GBA2 Wikipedia(Text) CC BY-SA