Gillis is a surname. Notable people with the surname include:
Alan Gillis (born 1936), Irish politicianAnn Gillis (born 1927), American actressBrad Gillis (born 1957), American musicianChristopher Gillis (1951–1993), Canadian dancer and choreographerClarence Gillis (1895–1960), Canadian politicianDon Gillis (1922–2008), American radio and television personalityDon Gillis (1912–1978), American composer, conductor and teacherDuncan Gillis (1883–1963), Canadian athleteGregg Gillis (born 1981), American musician known as Girl TalkHugh Gillis (1918–2013), American politicianJames Gillis (bishop) (1802–1864), Scottish bishopJames Lisle Gillis (1792–1881), American politicianJames Henry Gillis (1831–1910), Rear Admiral in the United States NavyJamie Gillis (1943-2010), American porn starJohn Anthony Gillis (born 1975), American musician known as Jack WhiteJohn F. Gillis (1846–?), Canadian politicianJohn P. Gillis (1803–1873), Commodore in the United States NavyJohn R. Gillis, American historianLynette Gillis (born 1961), Canadian voice actressMichael Gillis (1949–2007), American academicPeter B. Gillis (born 1952), American comic book writerPieter Gillis (1486–1533), European humanist and printerS. Malcolm Gillis (born 1941), American academic