Gillis is a surname. Notable people with the surname include:
Alan Gillis (born 1936), Irish politician
Ann Gillis (born 1927), American actress
Brad Gillis (born 1957), American musician
Christopher Gillis (1951–1993), Canadian dancer and choreographer
Clarence Gillis (1895–1960), Canadian politician
Don Gillis (1922–2008), American radio and television personality
Don Gillis (1912–1978), American composer, conductor and teacher
Duncan Gillis (1883–1963), Canadian athlete
Gregg Gillis (born 1981), American musician known as Girl Talk
Hugh Gillis (1918–2013), American politician
James Gillis (bishop) (1802–1864), Scottish bishop
James Lisle Gillis (1792–1881), American politician
James Henry Gillis (1831–1910), Rear Admiral in the United States Navy
Jamie Gillis (1943-2010), American porn star
John Anthony Gillis (born 1975), American musician known as Jack White
John F. Gillis (1846–?), Canadian politician
John P. Gillis (1803–1873), Commodore in the United States Navy
John R. Gillis, American historian
Lynette Gillis (born 1961), Canadian voice actress
Michael Gillis (1949–2007), American academic
Peter B. Gillis (born 1952), American comic book writer
Pieter Gillis (1486–1533), European humanist and printer
S. Malcolm Gillis (born 1941), American academic
