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George Brownlee

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Name  George Brownlee

Fields  Pathology
George Brownlee George Brownlee Royal Society
Born  George Gow Brownlee 13 January 1942 (age 73) (1942-01-13)
Institutions  University of Cambridge University of Oxford Laboratory of Molecular Biology Sir William Dunn School of Pathology
Thesis  Nucleotide sequences in the low molecular weight ribosomal ribonucleic acid of Escherichia coli (1967)
Notable awards  Colworth Medal (1976) FRS (1987) FMedSci (1998)
Spouse  Margaret Susan Kemp (m. 1966)
Institution  University of Cambridge, University of Oxford

Alma mater  University of Cambridge
Doctoral advisor  Frederick Sanger

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Professor George Gow Brownlee FRS FMedSci is a British pathologist and Fellow of Lincoln College, Oxford.

Contents

Education

Brownlee was educated at Dulwich College and Emmanuel College, Cambridge where he studied Natural Sciences and was awarded a Master of Arts degree followed by PhD in 1967 for research on nucleotides supervised by Fred Sanger.

Career and Research

Brownlee was Professor of Chemical Pathology at Sir William Dunn School of Pathology, from 1978 to 2008.

Brownlee cloned and expressed human clotting factor IX, providing a recombinant source of this protein for Haemophilia B patients who had previously relied on the hazardous blood-derived product.

With Merlin Crossley he helped discover the two sets of genetic mutations that were preventing two key proteins from attaching to the DNA of people with a rare and unusual form of Haemophilia B – Haemophilia B Leyden – where sufferers experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. This lack of protein attachment to the DNA was thereby turning off the gene that produces clotting factor IX, which prevents excessive bleeding.

With Peter Palese and co-workers he developed the first reverse genetics system for influenza virus, markedly speeding up the process of developing influenza vaccines.

Brownlee authored a biography of Fred Sanger published in 2014.

Awards and honours

Brownlee was awarded The Colworth Medal by the Biochemical Society in 1976 and elected a Fellow of the Royal Society (FRS) in 1987. His certificate of election and candidature reads:

Brownlee was also elected a Fellow of the Academy of Medical Sciences (FMedSci)]] in 1998 and an EMBO Member in 1979.

References

George Brownlee Wikipedia


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