Species Human Entrez 2950 | Human Mouse Ensembl ENSG00000084207 | |
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Aliases GSTP1, DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI, glutathione S-transferase pi 1 External IDs MGI: 3782108 HomoloGene: 660 GeneCards: GSTP1 | ||
Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.
Contents
Gene music using protein sequence of gstp1 glutathione s transferase pi 1
Function
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Interactions
GSTP1 has been shown to interact with Fanconi anemia, complementation group C and MAPK8.
GST-Pi is expressed in many human tissues, particularly in the biliary tree and renal distal convoluted tubules.
Possible drug target
Triple-negative breast cancer cells rely on glutathione-S-transferase Pi1, and inhibitors are being studied. Piperlongumine has been found to silence the gene.