Rahul Sharma (Editor)

GRIN2B

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Species
  
Human

Entrez
  
2904

Human
  
Mouse

Ensembl
  
ENSG00000273079

GRIN2B

Aliases
  
GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B

External IDs
  
MGI: 95821 HomoloGene: 646 GeneCards: GRIN2B

Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene.

Contents

NMDA receptors

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. The NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heterotetramers composed of two molecules of the key receptor subunit NMDAR1 (GRIN1) and two drawn from one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.

Function

NR2B has been associated with age- and visual-experience-dependent plasticity in the neocortex of rats, where an increased NR2B/NR2A ratio correlates directly with the stronger excitatory LTP in young animals. This is thought to contribute to experience-dependent refinement of developing cortical circuits.

Both mice and rats that were engineered to over-express GRIN2B in their brains have increased mental ability.

Ligands

  • Besonprodil
  • CERC-301, a selective NR2B receptor antagonist
  • Eliprodil
  • Evt 101, a selective NR2B receptor antagonist. This compound was tested as a potentially fast-acting antidepressant. In 2011 it was voluntarily withdrawn from a Phase II clinical study in treatment-resistant depression due to an unsatisfactory toxicity profile.
  • Ro-25-6981 (also known as MI-4), a selective NR2B receptor antagonist
  • Traxoprodil, a selective NR2B receptor antagonist

    • Interactions

    GRIN2B has been shown to interact with:

    References

    GRIN2B Wikipedia
    (Text) CC BY-SA


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