Species Human Entrez 2822 | Human Mouse Ensembl ENSG00000112293 | |
 | ||
Aliases GPLD1, GPIPLD, GPIPLDM, PIGPLD, PIPLD, glycosylphosphatidylinositol specific phospholipase D1 External IDs MGI: 106604 HomoloGene: 1152 GeneCards: GPLD1 | ||
Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
Interactions
GPLD1 has been shown to interact with Apolipoprotein A1 and APOA4.
References
GPLD1 Wikipedia(Text) CC BY-SA