Symbol POFUT2 Entrez 23275 OMIM 610249 | Alt. symbols C21orf80 HUGO 14683 RefSeq NM_133634 | |
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
References
GDP-fucose protein O-fucosyltransferase 2 Wikipedia(Text) CC BY-SA