Species Human Entrez 6529 | Human Mouse Ensembl ENSG00000157103 | |
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Aliases SLC6A1, GABATHG, GABATR, GAT1, MAE, GABA transporter 1, solute carrier family 6 member 1 External IDs MGI: 95627 HomoloGene: 2290 GeneCards: SLC6A1 | ||
GABA transporter 1 (GAT1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.
Contents
Function
GAT1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. GABA Transporter 1 uses Na+ and Cl- to create a gradient, which removes or adds GABA to extracellular spaces in the cerebrum and cerebellum. The stoichiometry for GABA Transporter 1 is 2 Na+: 1 Cl-: 1 GABA. The activity of GAT1 is largely dependent on the presence of Na+, while Cl- assists by increasing the ability for GAT-1 to uptake GABA.
Diseases
Research recorded in The American Journal of Psychiatry has shown that schizophrenia patients have GABA synthesis and expression altered, leading to the conclusion that GABA Transporter-1, which adds and removes GABA from the synaptic cleft, plays a role in the development of neurological disorders such as Schizophrenia.
Interactions
SLC6A1 has been shown to interact with STX1A.