The film received negative reviews, however it was considered an improvement over the original. The Nickelodeon TV premiere drew 5.7 million viewers.
Fred goes into music class to find his favourite teacher, Mrs. Felson, has been replaced by a teacher named Mr. Devlin. Walking home from school, Fred notices a strange girl named Talia following him. Fred believes he is being stalked, but the girl just walks the same way to school as him. Spying on Devlin that night, Fred sees him burying something, which he suspects is the body of Mrs. Felson. Kevin's mother invites Fred and his mother to a party for Mr. Devlin. At the party, Fred's mother falls for Mr. Devlin, and Fred learns that Talia is actually Kevin's sister.
The next day, Fred becomes extremely suspicious of Devlin and reaches the conclusion that he is a vampire. Mr. Devlin takes Fred's mother on a date, so Fred enlists his friend Bertha to spy on them. At a restaurant, Fred and Bertha learn that Mr. Devlin doesn't like garlic on his fries, making them all the more suspicious. Later that night, Fred's imaginary Dad brings him to a wrestling arena, where they tag team against Mr. Devlin and Kevin.
Fred is horrified at school the following day to discover Mr. Devlin running a blood drive at school. He's even more worried to discover Bertha taking personal music lessons from Devlin. Fred gathers items to use as weapons against Devlin, planning to defeat him at the school piano recital. Fred arms himself with him various tools and goes on a shooting spree of garlic sauce at the recital, soaking everyone except Devlin.
Mr. Devlin invites him into his house for dinner after the fiasco, so that they can bury the hatchet. Fred sets up a live video streaming from his cell phone so he can prove to his classmates that Devlin is a vampire. After showing off Devlin's living room and digging for "bodies", Fred discovers a secret butchers' room behind a wall filled with meat and bones. As Fred investigates, Devlin creeps in with a long knife and a tall head-dress. Fred then drops his phone into a pot of boiling liquid, freezing on Devlin, and the image of Devlin in his headdress causes everyone watching the video to think that he is a vampire. But after Devlin explains every weird hobby he has, Fred starts to relate to him, and he comes to realize Devlin is not a vampire, just an eccentric and cultural music teacher.
Everyone at Fred's school has seen his video, which makes everyone believe that Devlin is a vampire. Fred runs to Devlin's house to apologize, but Devlin is too depressed to answer. When Fred learns Devlin has gotten fired and put up a "for sale" sign for his house, he feels guilty and decides to fix things by making everyone think he himself is the vampire. Bertha and Talia both help, as Talia reveals how much she dislikes her brother. Kevin and his friends go up to Devlin's house because they think he has kidnapped Talia. Fred walks out of the garage carrying her, threatening to turn her into a vampire. Bertha makes Kevin stab Fred, and he gets sprayed with fake blood, making everyone believe Fred really is a vampire. Devlin accepts Fred's apology, revealing that he quit his job and sold his house of his own choice, but still sees Fred as his one true friend. As Fred's mother and Devlin go out for a good-bye snack, Fred looks at the mirror in his house and sees that Mr. Devlin has no reflection, revealing that he was a vampire after all.Lucas Cruikshank as Fred Figglehorn/Derf Nrohelggif: Fred is a socially awkward and extremely hyperactive sixteen-year-old living with his mother. Derf is a mysterious stranger who resembles the opposite of Fred.
Seth Morris as Mr. Jake Devlin, the new music teacher and Fred's new neighbor.
Siobhan Fallon Hogan as Hilda Figglehorn, Fred's rather insane mother.
Daniella Monet as Bertha, Fred's best friend who wears bizarre clothing, but cares little for what others think. Monet replaces Jennette McCurdy from the previous film.
Jake Weary as Kevin; a bully who lives across the street from Fred. He constantly bullies Fred.
Ariel Winter as Talia, the new girl in school and Kevin's sister, and Talia wants Kevin to be nice to Fred.
Stephanie Courtney as Kevin's mother.
John Cena as Mr. Figglehorn, Fred's imaginary dad who appears almost out of nowhere to offer Fred advice and support throughout the film. He lives in the family's refrigerator.
Carlos Knight as Diesel, Kevin's best friend.
Matthew Scott Montgomery as Teen Manager.
Talon Reid as Kevin's Friend
Jay Jay Warren as Younger Kevin
Pixie Lott as Judy. The pretty English girl. (archive footage only and singing voice heard. Cruikshank later revealed on his vlog that Lott's management would not let her appear in any further Fred films.)
The music played during the scene when Mr. Devlin and Kevin go in the ring when Fred is dreaming is Blood used by the former professional wrestling stable The Brood.
The film received mostly negative reviews. However, it was not as negative as the previous Fred film was. As of October 13th, 2015, the film has a score of 3.1 based on 1,165 votes on IMDb. Common Sense Media gave the film 2 out of 5 stars based on 23 reviews. Review aggregator Rotten Tomatoes gave the film a rating of 37% based on 453 audience votes.
The initial American television premiere on the channel Nickelodeon drew 5.7 million viewers, down from the previous film's premiere of 7.6 million. However it ranked sixth in the most watched for overall weekly cable programming. The second showing, the following Sunday at 11:00 AM, drew 3.7 million viewers, enough to rank it as the fourteenth most watched weekly cable programming. The final primetime broadcasting on October 30 drew in 3.2 million views, which ranked the program within the top 20 of cable programming for the night.
A third film was released on July 28, 2012 called Fred 3: Camp Fred.This was the last film to be released.
Fred 2: Night of the Living Fred was released on DVD on February 6, 2012.