The children are taking care of their baby brothers and sisters on a Saturday, but would much rather go swimming. They blackmail Spanky into doing the job for them, by threatening to reveal that he broke a neighbor's window. Spanky is left at home alone to mind all the babies.
He tells them a long, fractured story about Tarzan, but one baby slips away unnoticed and climbs the stairs. As Spanky hurries to bring him down with a cushion, the others start causing havoc around the house, such as tossing fish out of their bowl, throwing food from the icebox onto the kitchen floor for Pete the dog to eat, and using a vacuum cleaner to spray flour all over the kitchen. To keep the stair-climbing baby out of trouble, Spanky pours glue on the floor and makes him sit in it.
As he tries in vain to rein in the other babies, one of them turns on a radio (broadcasting a murder mystery), dials a telephone, and leaves the receiver in range of the speaker. The operators hear the broadcast and call the police, thinking that an actual murder is taking place. The police reach the house, find the radio, and confront the children when they return from swimming. As the water from an overflowing upstairs bathtub leaks through the ceiling, the children explain that they left Spanky in charge of the babies. They find him in the kitchen, where he has put two of the babies in birdcages; glued a third to the floor; used a chair, spittoons, and flatirons to immobilize a fourth; and barricaded Pete in a breadbox.
George McFarland as Spanky
Matthew Beard as Stymie
Tommy Bond as Tommy
Dorothy DeBorba as Dorothy
Bobby Hutchins as Wheezer
Dickie Moore as Dickie
John Collum as Uh-huh
Dickie Jackson as Dickie
David Holt - Our Gang member
Pete the Pup as Himself
Bobbie Beard as Cotton
Dickie Hutchins as Baby who says "Remarkable"
Tommy McFarland - Baby who breaks a lamp, jumps on the bed and overflows the bath tub
Murlin Powers as Baby
Duke Sexton as Baby
Harry Bernard as Officer
Estelle Etterre as Nemo's girl friend in broadcast / Telephone company operator
Billy Gilbert as Radio station NIX announcer / Dr. Nemo, serial character