Entrez 2495 | Ensembl ENSG00000167996 | |
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Aliases FTH1, FHC, FTH, FTHL6, HFE5, PIG15, PLIF, ferritin, heavy polypeptide 1, ferritin heavy chain 1 External IDs MGI: 95588 HomoloGene: 74295 GeneCards: FTH1 | ||
Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.
Contents
Function
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Interactions
FTH1 has been shown to interact with Ferritin light chain.