Entrez 2290 | Ensembl ENSG00000176165 | |
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Aliases FOXG1, BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF-3, HBF-G2, HBF2, HFK1, HFK2, HFK3, KHL2, QIN, forkhead box G1 External IDs MGI: 1347464 HomoloGene: 3843 GeneCards: FOXG1 | ||
Function
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon. It likely causes problems if it is mutated in children. Mutations cause high levels of mortality.
Cajal Retzius Cell development is regulated by Foxg1
FOXG1 syndrome
FOXG1 syndrome is characterized by microcephaly and brain malformations. It affects most aspects of development and can cause seizures. FOXG1 syndrome is classified as an Autism Spectrum Disorder and was previously considered a variant of Rett Syndrome.
Interactions
FOXG1 has been shown to interact with JARID1B.
References
FOXG1 Wikipedia(Text) CC BY-SA