Species Human Entrez 2287 | Human Mouse Ensembl ENSG00000100442 | |
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Aliases FKBP3, FKBP-25, FKBP-3, FKBP25, PPIase, FK506 binding protein 3 External IDs MGI: 1353460 HomoloGene: 1525 GeneCards: FKBP3 | ||
Gene music using protein sequence of fkbp3 fk506 binding protein 3
FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.
Contents
Function
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Interactions
FKBP3 has been shown to interact with YY1, HDAC1, Histone deacetylase 2 and Mdm2.
References
FKBP3 Wikipedia(Text) CC BY-SA