Species Human Entrez 2286 | Human Mouse Ensembl ENSG00000173486 | |
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Aliases FKBP2, FKBP-13, PPIase, FK506 binding protein 2 External IDs MGI: 95542 HomoloGene: 40604 GeneCards: FKBP2 | ||
FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.
Contents
Function
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.
Interactions
FKBP2 has been shown to interact with ARFGEF1 and EPB41L2.