Suvarna Garge

ARFGEF1

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
Species  Human
Entrez  10565
Human  Mouse
Ensembl  ENSG00000066777
ARFGEF1
Aliases  ARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs  MGI: 2442988 HomoloGene: 4687 GeneCards: ARFGEF1

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

Contents

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

Interactions

ARFGEF1 has been shown to interact with FKBP2, ARFGEF2 and PRKAR1A.

References

ARFGEF1 Wikipedia


Similar Topics
Little Accidents
Sergio Rouco
Kevin Dunn (musician)
Topics