Rahul Sharma (Editor)

FBXO4

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Species
  
Entrez
  
26272

Human
  
Ensembl
  
ENSG00000151876

FBXO4

Aliases
  
FBXO4, FBX4, F-box protein 4

External IDs
  
MGI: 2146220 HomoloGene: 8134 GeneCards: FBXO4

F-box only protein 4 is a protein that in humans is encoded by the FBXO4 gene.

Contents

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Interactions

FBXO4 has been shown to interact with:

  • CUL1, and
  • SKP1A.
  • References

    FBXO4 Wikipedia


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