Entrez 26224 | Ensembl ENSG00000005812 | |
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Aliases FBXL3, FBL3, FBL3A, FBXL3A, F-box and leucine-rich repeat protein 3, F-box and leucine rich repeat protein 3 External IDs OMIM: 605653 MGI: 1354702 HomoloGene: 8127 GeneCards: FBXL3 | ||
F-box/LRR-repeat protein 3 is a protein that in humans is encoded by the FBXL3 gene.
Contents
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD40 repeats, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.
Interactions
FBXL3 has been shown to interact with SKP1A.