Entrez 7430 | Ensembl ENSG00000092820 | |
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Aliases EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin External IDs MGI: 98931 HomoloGene: 55740 GeneCards: EZR | ||
Gene music using protein sequence of ezr ezrin
Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.
Contents
- Gene music using protein sequence of ezr ezrin
- Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote
- Structure
- Function
- Interactions
- References
Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote
Structure
The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain.
Function
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.
The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol(4,5)bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2.
Interactions
VIL2 has been shown to interact with:
