Samiksha Jaiswal (Editor)

Etiocholanolone

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Covid-19
ATC code  none
PubChem CID  5880
ChemSpider  5669
CAS ID  53-42-9
CAS Number  53-42-9
DrugBank  DB02854
Molar mass  290.445 g/mol
Etiocholanolone
Synonyms  Aetiocholanolone 5-Isoandrosterone

Medical vocabulary what does etiocholanolone mean


Etiocholanolone, also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. It causes fever, immunostimulation, and leukocytosis, and is used to evaluate adrenal cortex function, bone marrow performance, and in neoplastic disease to stimulate the immune system. Etiocholanolone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of etiocholanolone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form.

Etiocholanolone is produced from 5β-dihydrotestosterone, with 3α,5β-androstanediol as an intermediate.

References

Etiocholanolone Wikipedia


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