MedlinePlus a682022 Routes of
administration By mouth (tablets) Biological half-life 3–9 hours CAS ID 86-35-1 | Pregnancy
category C ATC code N03AB01 (WHO) Molar mass 204.225 g/mol | |
AHFS/Drugs.com Consumer Drug Information | ||
Ethotoin can be used to treat epilepsy overview
Ethotoin (marketed as Peganone by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin.
Contents
Ethotoin medication uses and side effects
Mechanism of action
Similar to phenytoin.
Approval history
Indications and usage
Ethotoin is indicated for tonic-clonic and partial complex seizures.
Dosing
Ethotoin is available in 250 mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.
Side effects
Ataxia, visual disturbances, rash and gastrointestinal problems.
Chemistry
Ethotoin, 3-ethyl-5-phenylimidazolidine-2,4-dione, is synthesized by the reaction of benzaldehyde oxynitrile, with urea or ammonium hydrocarbonate, which forms an intermediate urea derivative which on acidic conditions cyclizes to 5-phenylhydantoin. Alkylation of this product using ethyliodide leads to the formation of ethotoin.
References
Ethotoin Wikipedia(Text) CC BY-SA