Suvarna Garge (Editor)

Ethotoin

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MedlinePlus
  
a682022

Routes ofadministration
  
By mouth (tablets)

Biological half-life
  
3–9 hours

CAS ID
  
86-35-1

Pregnancycategory
  
C

ATC code
  
N03AB01 (WHO)

Molar mass
  
204.225 g/mol

AHFS/Drugs.com
  
Consumer Drug Information

Ethotoin can be used to treat epilepsy overview


Ethotoin (marketed as Peganone by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin.

Contents

Ethotoin medication uses and side effects


Mechanism of action

Similar to phenytoin.

Approval history

  • 1957 Peganone was granted Food and Drug Administration (FDA) approval to Abbott Laboratories for treatment of grand mal (tonic clonic) and partial complex (psychomotor) seizures.
  • 2003 Peganone was acquired from Abbott Laboratories by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

    • Indications and usage

    Ethotoin is indicated for tonic-clonic and partial complex seizures.

    Dosing

    Ethotoin is available in 250 mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.

    Side effects

    Ataxia, visual disturbances, rash and gastrointestinal problems.

    Chemistry

    Ethotoin, 3-ethyl-5-phenylimidazolidine-2,4-dione, is synthesized by the reaction of benzaldehyde oxynitrile, with urea or ammonium hydrocarbonate, which forms an intermediate urea derivative which on acidic conditions cyclizes to 5-phenylhydantoin. Alkylation of this product using ethyliodide leads to the formation of ethotoin.

    References

    Ethotoin Wikipedia
    (Text) CC BY-SA


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