Entrez 2049 | Ensembl ENSG00000182580 | |
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Aliases EPHB3, ETK2, HEK2, TYRO6, EPH receptor B3 External IDs MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3 |
Function
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
Interactions
EPHB3 has been shown to interact with MLLT4 and RAS p21 protein activator 1.