Samiksha Jaiswal (Editor)

EPHB3

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Species
  
Human

Entrez
  
2049

Human
  
Mouse

Ensembl
  
ENSG00000182580

EPHB3

Aliases
  
EPHB3, ETK2, HEK2, TYRO6, EPH receptor B3

External IDs
  
MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.

Contents

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Interactions

EPHB3 has been shown to interact with MLLT4 and RAS p21 protein activator 1.

References

EPHB3 Wikipedia