She was born Edith Ann Tarbox in Dripping Springs, Texas.
Hill earned her bachelor's degree in journalism from the University of Texas at Austin, located in Austin, Texas, where she was a member of Delta Gamma Sorority.
She was a VJ for VH1 from September 1986 to August 1987. Moving from there to journalism, she spent time at WPXI-TV, WHDH-TV, and WABC-TV where she was brought in to co-anchor the station's morning newscast as well as its just launched midday broadcast. During this time Hill was still using her maiden name, Edye Tarbox.
In 1998, Hill joined the Fox News Channel, where she served as an anchor for Fox and Friends from 1998 to 2006. She later moved to the 2:00 p.m. hour after serving as host of the 11:00 a.m. to 12:00 noon block of Fox News Live from 2006 until her show America's Pulse was canceled in 2008. She also co-hosted Bill O'Reilly's The Radio Factor for five years. She had also substituted for Bill O'Reilly on The O'Reilly Factor.
In 2007, the television-industry blog TV Newser reported that it had been given a copy of an internal Fox News Channel memorandum that gave the following description of America's Pulse: "During this hour, E.D. will present the news in a fair & balanced way with her own passionate style and sense of humor."
On the June 6, 2008, episode of America's Pulse, Hill asked whether a fist bump between then-presidential candidate Barack Obama, and his wife Michelle, after the final 2008 Presidential Democratic primaries was a "terrorist fist jab". Hill, introducing an upcoming discussion before a commercial break, posited that the gesture was either "A fist bump? A pound? [or] A terrorist fist jab?," but never explained the term when the segment continued after the break. The incident set off a controversy among bloggers and television commentators. Hill apologized for her comments the next day. The next week, the Fox News Channel announced that Hill's show America's Pulse had been canceled. Martha McCallum's show The Live Desk would become two hours (1–3 p.m.), and Trace Gallagher would become a co-host with McCallum.
In November 2008, after the general election, it was announced that Hill's contract with Fox would not be renewed. She would continue with the network until her contract expired. Senior Vice President of Programming at Fox Bill Shine says that he "chose not to renew E.D.'s latest contract" but noted that "Hill has been a valued contributor to the success of FNC over the years, and we wish her all the best".
On October 14, 2008, Hill was a guest co-host of the ABC daytime show The View, then returned to co-host again on September 23 and 25, 2009, while Elisabeth Hasselbeck was on maternity leave; she also hosted on July 28, 2010, while Barbara Walters was on leave.
In February 2011, it was announced that she would be joining the staff of In the Arena with Eliot Spitzer on CNN, but just five months later CNN elected to cancel the show instead.
Glenn Beck announced on his GBTV Show August 20, 2012 that E.D. Hill will be part of GBTV's on-site coverage of the 2012 Republican National Convention in Tampa, FL.
On October 6, 2012, Hill moderated The Rumble in the Air-Conditioned Auditorium, a debate between Bill O'Reilly and Jon Stewart.
Hill won a local Emmy Award for Outstanding News Special while working for WHDH-TV in Boston (1990–91), and has also received a Golden Quill Award for live spot news reporting.
In November 2005 William Morrow published Hill's first book, a collection of personal profiles entitled Going Places: How America's Best and Brightest Got Started Down the Road of Life. Her next book, I'm Not Your Friend, I'm Your Parent, was published in the United States 2007 and published in China in 2010.
On 29 April 1989, while a news anchor at WPXI-TV in Pittsburgh, she married Marc Philip Weill (the son of financier Sanford Weill), at the time a vice president of Smith Barney, Harris Upham & Company in New York City, New York. They had two children [daughter Laurel in 1992, son Matthew in 1994] and divorced in 1995.
Her second marriage was to J. David Donahey, with whom she has son J. David Jr [born in 1997].
In February 2002 she announced her engagement to her boyfriend of two year venture capitalist Joe Hill. They married 1 June 2002. He has three children from a previous marriage: Jordan, Collin, and Wyatt. Together they have a daughter, Sumner Holcomb Hill [February 2003], and a son Joseph Wolf Hill [February 2004].
In February 2010 she underwent a preventative double mastectomy