Dual specificity kinase

Updated on Oct 29, 2023

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EC number 2.7.12.1 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 134549-83-0 BRENDA BRENDA entry KEGG KEGG entry

In biochemistry, a dual-specificity kinase (EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase.

MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:

ADK1

Arabidopsis dual specificity kinase 1

CLK1, CLK2, CLK3, CLK4

DSTYK

DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4

Mps1p

TESK1, TESK2

TTK

The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).

References

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