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Dopamine receptor D1

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Species
  
Human

Entrez
  
1812

Human
  
Mouse

Ensembl
  
ENSG00000184845

Dopamine receptor D1 Figure 1 Neuroscience Fragile dopamine Nature

Aliases
  
DRD1, dopamine receptor D1, DADR, DRD1A

External IDs
  
MGI: 99578 HomoloGene: 30992 GeneCards: DRD1

Gene music using protein sequence of drd1 dopamine receptor d1


Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.

Contents

Function

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This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor is Gs/a coupled and indirectly activates cyclic AMP-dependent protein kinase; stimulating the neuron. nuD1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternative transcription initiation sites result in two transcript variants of this gene. D1-D2 dopamine receptor heteromer formation is observed.

Production

Dopamine receptor D1 Dopamine and Anorexia Nervosa Tackling the Myths Part I Intro

The DRD1 gene expresses primarily in the caudate putamen in humans, and in the caudate putamen, the nucleus accumbens and the olfactory tubercle in mouse. Gene expression patterns from the Allen Brain Atlases in mouse and human can be found here.

Ligands

There are a number of ligands selective for the D1 receptors. To date, most of the known ligands are based on dihydrexidine or the prototypical benzazepine partial agonist SKF-38393 (one derivative being the prototypical antagonist SCH-23390). D1 receptor has a high degree of structural homologine to another dopamine receptor, D5, and they both bind similar drugs. As a result, none of the known ligands is selective for the D1 vs. the D5 receptor, but the benzazepines generally are more selective for the D1 and D5 receptors versus the D2-like family. Some of the benzazepines have high intrinsic activity whereas others do not.

Agonists

Dopamine receptor D1 Dopamine receptor D1 Wikipedia

Several D1 receptor agonists are used clinically. These include apomorphine, pergolide, rotigotine, and terguride. All of these drugs are preferentially D2-like receptor agonists. Fenoldopam is a selective D1 receptor partial agonist that does not cross the blood-brain-barrier and is used intravenously in the treatment of hypertension. Dihydrexidine and adrogolide (ABT-431) (a prodrug of A-86929 with improved bioavailability) are the only selective, centrally active D1-like receptor agonists that have been studied clinically in humans. They produced dose-limiting profound hypotension and dyskinesias, respectively, and were not further developed for clinical use.

List of D1 receptor agonists

  • Dihydrexidine derivatives
  • A-86929 - full agonist with 14-fold selectivity for D1-like receptors over D2
  • Dihydrexidine - full agonist with 10-fold selectivity for D1-like receptors over D2 that has been in Phase IIa clinical trials as a cognitive enhancer. It also showed profound antiparkinson effects in MPTP-treated primates, but caused profound hypotension in one early clinical trial in Parkinson's disease. Although dihydrexidine has significant D2 properties, it is highly biased at D2 receptors and was used for the first demonstration of functional selectivity with dopamine receptors.
  • Dinapsoline - full agonist with 5-fold selectivity for D1-like receptors over D2
  • Dinoxyline - full agonist with approximately equal affinity for D1-like and D2 receptors
  • Doxanthrine - full agonist with 168-fold selectivity for D1-like receptors over D2
  • Benzazepine derivatives
  • SKF-81297 - 200-fold selectivity for D1 over any other receptor
  • SKF-82958 - 57-fold selectivity for D1 over D2
  • SKF-38393 - very high selectivity for D1 with negligible affinity for any other receptor
  • Fenoldopam - highly selective peripheral D1 receptor partial agonist used clinically as an antihypertensive
  • 6-Br-APB - 90-fold selectivity for D1 over D2
  • Others
  • Stepholidine - alkaloid with D1 agonist and D2 antagonist properties, showing antipsychotic effects
  • A-68930
  • A-77636
  • CY-208,243 - high intrinsic activity partial agonist with moderate selectivity for D1-like over D2-like receptors, member of ergoline ligand family like pergolide and bromocriptine.
  • SKF-89145
  • SKF-89626
  • 7,8-Dihydroxy-5-phenyl-octahydrobenzo[h]isoquinoline: extremely potent, high-affinity full agonist
  • Cabergoline - weak D1 agonism, highly selective for D2, and various serotonin receptors
  • Pergolide - (similar to cabergoline) weak D1 agonism, highly selective for D2, and various serotonin receptors

    • Antagonists

    Many typical and atypical antipsychotics are D1 receptor antagonists in addition to D2 receptor antagonists. No other D1 receptor antagonists have been approved for clinical use. Ecopipam is a selective D1-like receptor antagonist that has been studied clinically in humans in the treatment of a variety of conditions, including schizophrenia, cocaine abuse, obesity, pathological gambling, and Tourette's syndrome, with efficacy in some of these conditions seen. The drug produced mild-to-moderate, reversible depression and anxiety in clinical studies however and has yet to complete development for any indication.

    List of D1 receptor antagonists

  • Benzazepine derivatives
  • SCH-23,390 - 100-fold selectivity for D1 over D5
  • SKF-83,959 - 7-fold selectivity for D1 over D5 with negligible affinity for other receptors; acts as an antagonist at D1 but as an agonist at D5
  • Ecopipam (SCH-39,166) - a selective D1/D5 antagonist that was being developed as an anti-obesity medication but was discontinued

    • Protein–protein interactions

    Dopamine receptor D1 has been shown to interact with:

  • COPG2,
  • COPG, and
  • DNAJC14.

    • Receptor oligomers

    The D1 receptor forms heteromers with the following receptors: dopamine D2, D3, histamine H3, μ opioid.

  • D1–D2
  • D1−H3−NMDA receptor complex − a target to prevent neurodegeneration

    • References

    Dopamine receptor D1 Wikipedia
    (Text) CC BY-SA