Donohue is an originally an Irish surname which is abbreviated from O Donohue. (Irish: Ó Donnachú). Notable people with the surname include:
Adam Donohue (born 1990), Australian rules footballer
Charles D. Donohue (1880–1928), New York politician and judge
David Donohue (born 1967), American race car driver
Erin Donohue (born 1983), American Track & Field athlete
Harold Donohue (1901–1984), American politician
Jack Donohue (disambiguation), several people
Jerry Donohue (1920–1985), American theoretical and physical chemist
Jim Donohue (born 1938), American baseball player
Keith Donohue (disambiguation), several people
Kether Donohue (born 1985), actress
Larry Donohue (born 1955), former Australian rules footballer
Mark Donohue (1937–1975), American racecar driver
Mary Donohue (born 1947), New York lieutenant governor and judge
Niall Donohue (1990–2013), Irish hurler
Nigel Donohue (born 1969), British judoka
Pat Donohue (born 1953), American fingerstyle guitarist
Pete Donohue (1900–1988), American baseball player
Peter M. Donohue (21st century), American Roman Catholic priest
Tom Donohue (born 1952), retired professional baseball player
Tom J. Donohue (born 1938), President and CEO of the United States Chamber of Commerce
William Anthony Donohue (born 1947), American president of the Catholic League for Religious and Civil Rights in the United States
William J. Donohue (c. 1873–1907), New York politician