Donohue is an originally an Irish surname which is abbreviated from O Donohue. (Irish: Ó Donnachú). Notable people with the surname include:
Adam Donohue (born 1990), Australian rules footballerCharles D. Donohue (1880–1928), New York politician and judgeDavid Donohue (born 1967), American race car driverErin Donohue (born 1983), American Track & Field athleteHarold Donohue (1901–1984), American politicianJack Donohue (disambiguation), several peopleJerry Donohue (1920–1985), American theoretical and physical chemistJim Donohue (born 1938), American baseball playerKeith Donohue (disambiguation), several peopleKether Donohue (born 1985), actressLarry Donohue (born 1955), former Australian rules footballerMark Donohue (1937–1975), American racecar driverMary Donohue (born 1947), New York lieutenant governor and judgeNiall Donohue (1990–2013), Irish hurlerNigel Donohue (born 1969), British judokaPat Donohue (born 1953), American fingerstyle guitaristPete Donohue (1900–1988), American baseball playerPeter M. Donohue (21st century), American Roman Catholic priestTom Donohue (born 1952), retired professional baseball playerTom J. Donohue (born 1938), President and CEO of the United States Chamber of CommerceWilliam Anthony Donohue (born 1947), American president of the Catholic League for Religious and Civil Rights in the United StatesWilliam J. Donohue (c. 1873–1907), New York politician