De Bruyne is a Dutch surname meaning "the brown one". The name is variably spelled Debruyne or De Bruijne as well. More common forms are De Bruin, De Bruijn, and De Bruyn. People with this surname include:
Donatien de Bruyne (1871–1935), French biblical scholar
Fred De Bruyne (1930–1994), Belgian road race cyclist
Hector De Bruyne (1917–1995), Belgian politician
Kevin De Bruyne (b. 1991), Belgian footballer
Kris De Bruyne (b. 1950), Belgian singer
Mattheus de Bruyne (1895–1973), Dutch military leader
Norman de Bruyne (1904–1997), British aircraft engineer and industrialist
Rykel de Bruyne, Dutch malacologist
