De Bruyne is a Dutch surname meaning "the brown one". The name is variably spelled Debruyne or De Bruijne as well. More common forms are De Bruin, De Bruijn, and De Bruyn. People with this surname include:
Donatien de Bruyne (1871–1935), French biblical scholarFred De Bruyne (1930–1994), Belgian road race cyclistHector De Bruyne (1917–1995), Belgian politicianKevin De Bruyne (b. 1991), Belgian footballerKris De Bruyne (b. 1950), Belgian singerMattheus de Bruyne (1895–1973), Dutch military leaderNorman de Bruyne (1904–1997), British aircraft engineer and industrialistRykel de Bruyne, Dutch malacologist