De Bruyn is a Dutch and Afrikaans surname. "Bruyn" or "bruijn" is an archaic spelling of "bruin", meaning "brown". People with the name include:
Aad de Bruyn (1910–?), Dutch 35-fold national champion in discus, shot put and hammer throw
Abraham de Bruyn (c.1539–1587), Flemish engraver
Anna Maria de Bruyn (1708–1744), Dutch stage actress and ballet dancer
Cornelis Adriaan Lobry van Troostenburg de Bruyn (1857–1904), Dutch chemist
Erik de Bruyn (b. 1962), Dutch film director and actor
Ettiene de Bruyn (b. 1977), South African cricketer
Frans De Bruyn (b. 1924), Flemish writer
Günter de Bruyn (b. 1926), German author
Joe de Bruyn (b. 1949), Australian trade union official
John de Bruyn (b. 1956), Dutch-Canadian ice hockey goaltender
Louis de Bruyn (b. 1982) South African Master Builder at HLP Construction
Michelle De Bruyn (b. 1965), New Zealand professional football player
Nicolaes de Bruyn (1571–1656), Flemish engraver
Paul de Bruyn (1907–1997), German-American marathon runner
Pierre de Bruyn (b. 1977), South African cricketer
Piet De Bruyn (b. 1968), Belgian politician
Robert de Bruyn (b. 1991), South African rugby player
Sophia Williams-De Bruyn (b. 1938), South African anti-apartheid activist and provincial legislator
Stephanus De Bruyn (b. 1979), South African is a world leading Malware Analyst
Tewis de Bruyn (b. 1982), South African rugby player
Zander de Bruyn (b. 1975), South African cricketer
