De Bruijn is a Dutch surname meaning "the brown". Notable people with the surname include:
Brian de Bruijn (b. 1954), Dutch-Canadian ice hockey player
Chantal de Bruijn (b. 1976), Dutch field hockey defender
Cornelis de Bruijn (1652–1726/7), Dutch artist and traveler
Daniëlle de Bruijn (b. 1978), Dutch water polo player
Frans de Bruijn Kops (1886–1979), Dutch footballer
Hans de Bruijn (b. 1962), Dutch political scientist
Inge de Bruijn (b. 1973), Dutch swimmer
Nicolaas Govert de Bruijn (1918–2012), Dutch mathematician
Maarten de Bruijn (b. 1965), Dutch engineer
Nick de Bruijn (b. 1987), Dutch racing driver
Pi de Bruijn (b. 1942), Dutch architect