De Bruijn is a Dutch surname meaning "the brown". Notable people with the surname include:
Brian de Bruijn (b. 1954), Dutch-Canadian ice hockey playerChantal de Bruijn (b. 1976), Dutch field hockey defenderCornelis de Bruijn (1652–1726/7), Dutch artist and travelerDaniëlle de Bruijn (b. 1978), Dutch water polo playerFrans de Bruijn Kops (1886–1979), Dutch footballerHans de Bruijn (b. 1962), Dutch political scientistInge de Bruijn (b. 1973), Dutch swimmerNicolaas Govert de Bruijn (1918–2012), Dutch mathematicianMaarten de Bruijn (b. 1965), Dutch engineerNick de Bruijn (b. 1987), Dutch racing driverPi de Bruijn (b. 1942), Dutch architect