Darrell attended Thornwood High School in South Holland, Illinois, where he was a participant in football, track, wrestling, basketball, soccer and baseball. As a football player, he earned three letters in football, serving as captain and earning team MVP honors each of the last three seasons. He made 67 solo tackles as senior in 1998, along with 13 tackles for loss and four sacks. Played defensive end as sophomore, inside linebacker as junior and nose guard as senior. As a result, he was named USA Today honorable mention prep All-American pick, rated 82nd nationally on Chicago Sun-Times list of top 100 players, named first-team all-state pick in Illinois by Chicago Tribune, and named top player in SICA Blue. As a track & field participant, he was state qualifier.
After high school, Campbell signed a letter of intent to play college football at the University of Notre Dame where he would play for coaches Bob Davie and Tyrone Willingham. He enrolled in College of Arts and Letters, majoring in English and computer applications. During his senior season at Notre Dame in 2002, Campbell started all 13 games and recorded 30 tackles (7 for a loss) and 5 sacks.
Campbell was signed by Chicago Bears as an un-drafted rookie free agent and spent the 2005 season on the practice squad.
Began the 2006 season with the Cleveland Browns, but was released.
Later in 2006, he was signed to the Tampa Bay Buccaneers practice squad.
Played for the Orlando Predators, of the Arena Football League, in 2008. During his 8 games with the Predators, he recorded 19 total tackles, 1.5 sacks and 1 fumble recovery.
After the AFL season, he went back to the NFL when he attended Baltimore Ravens training camp and played in pre-season games, but failed to make the team.
In 2009, Campbell signed with the Montreal Alouettes of the Canadian Football League. The Alouettes went on to have a great season, as they won the 97th Grey Cup. Campbell was released after the season.
In 2011, Campbell was signed by the Philadelphia Soul of the AFL.
Campbell was a member of the Chicago Rush in 2012 & 2013.
When the Rush was no longer included in the league's plan for 2014, their players were distributed in a dispersal draft, where Campbell was selected by the Arizona Rattlers.
On December 5, 2013, Campbell was traded by the Rattlers to the expansion Portland Thunder for future considerations.