Species Human Entrez 1801 | Human Mouse Ensembl ENSG00000108963 | |
Aliases DPH1, DPH2L, DPH2L1, OVCA1, DEDSSH, diphthamide biosynthesis 1 External IDs MGI: 2151233 HomoloGene: 1059 GeneCards: DPH1 | ||
Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene. It encodes a protein that performs posttranslational modification of histidine-715 on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.
References
DPH1 Wikipedia(Text) CC BY-SA