Molar mass 297.354 g/mol | ||
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Gene music using protein sequence of dph3 diphthamide biosynthesis 3
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2).
Contents
Gene music using protein sequence of dph1 diphthamide biosynthesis 1
Structure
Diphthamide is proposed to be a 2-[3-carboxyamido-3-(trimethylammonio)propyl histidine. Though this structure has been confirmed by X-ray crystallography, its stereochemistry is uncertain.
Biological function
Diphthamide ensures translation fidelity.
The presence or absence of diphthamide is known to affect NF-κB or death receptor pathways.
Biosynthesis
Diphthamide is biosynthesized from histidine and S-adenosyl methionine.
References
Diphthamide Wikipedia(Text) CC BY-SA