Aliases DNMT3L Human Mouse Ensembl ENSG00000142182 | Species Human Entrez 29947 | |
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External IDs MGI: 1859287 HomoloGene: 8362 GeneCards: DNMT3L | ||
Gene music using protein sequence of dnmt3l dna cytosine 5 methyltransferase 3 like
DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene.
Contents
Function
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.
Interactions
DNMT3L has been shown to interact with HDAC1.