Siddhesh Joshi (Editor)

Corwin Hansch

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Nationality
  
American

Fields
  
Organic chemistry

Spouse
  
Gloria Hansch (m. 1944)

Name
  
Corwin Hansch


Corwin Hansch wwwtoxipediaorgdownloadthumbnails6017038Corw

Born
  
Corwin Herman Hansch October 6, 1918 Kenmare, North Dakota (
1918-10-06
)

Institutions
  
Pomona College Manhattan Project

Alma mater
  
University of Illinois New York University

Died
  
May 8, 2011, Claremont, California, United States

Books
  
Substituent Constants for Correlation Analysis in Chemistry and Biology

Education
  
New York University (1944), University of Illinois at Urbana–Champaign

Awards
  
Guggenheim Fellowship for Natural Sciences, US & Canada

Notable awards
  
Tolman Award (1975)

Corwin Herman Hansch (October 6, 1918 – May 8, 2011) was a Professor of Chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.'

Contents

Corwin Hansch Corwin Hansch 1918 2011 ChemViews Magazine ChemistryViews

Early life and childhood

He was born on October 6, 1918 in Kenmare, North Dakota.

Education

He earned a B.S. from the University of Illinois in 1940 and a Ph.D. from New York University in 1944.

Career

Hansch worked on the Manhattan Project at the University of Chicago and as a group leader at DuPont Nemours in Richland, Washington. In February 1946 he received an academic position at Pomona College.

Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.

Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.

He is also noted for the Hansch equation, which is used in

  • Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.
  • Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.
  • Hansch-Fujita π constant - The Hansch-Fujita π constant describes the contribution of a substituent to the lipophilicity of a compound.
  • Research Interests: Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).

  • Fragment based regression analysis for quantitative structure-activity relationship (Hansch-analysis)
  • Death

    He died of pneumonia on May 8, 2011 in Claremont, California at 92.

    References

    Corwin Hansch Wikipedia