Species Human Entrez 1394 | Human Mouse Ensembl n/a | |
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Aliases CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, CRHR, CRHR1L, CRHR1f, corticotropin releasing hormone receptor 1 External IDs MGI: 88498 HomoloGene: 20920 GeneCards: CRHR1 | ||
Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name. In humans, CRF1 is encoded by the CRHR1 gene.
Contents
Function
The corticotropin-releasing hormone receptor binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.
CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.
Evolution
Corticotrophin releasing hormone (CRH) evolved ~500 million years ago in an organism that subsequently gave rise to both chordates and arthropods. The binding site for this was single CRH like receptor. In vertebrates this gene was duplicated leading to the extant CRH1 and CRH2 forms. Additionally four paralogous ligands developed including CRH, urotenin-1/urocortin, urocortin 2 and urocortin 3.
Clinical significance
Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma.
CRF1 triggers cells to release hormones that are linked to stress and anxiety [original reference missing].Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.
Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn.
Interactions
Corticotropin-releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone and Urocortin.