Symbol Condensation Pfam clan CL0149 SCOP 1l5a | Pfam PF00668 InterPro IPR001242 SUPERFAMILY 1l5a | |
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In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.
References
Condensation domain Wikipedia(Text) CC BY-SA