Entrez 8161 | Ensembl ENSG00000121058 | |
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Aliases COIL, Coil, C79982, Cln80, p80, p80-coilin, coilin External IDs MGI: 104842 HomoloGene: 3413 GeneCards: COIL | ||
Vanhan coilin putsaus kuivapoltto pesu ja wikkaus
Coilin is a protein that in humans is encoded by the COIL gene. Coilin got its name from the coiled shape of the CB in which it is found. It was first identified using human autoimmune serum.
Contents
- Vanhan coilin putsaus kuivapoltto pesu ja wikkaus
- Kuinka vaihdat s2 vastuksen coilin
- Function
- References
Kuinka vaihdat s2 vastuksen coilin
Function
Coilin protein is one of the main molecular components of Cajal bodies (CBs). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. In addition to its structural role, coilin acts as glue to connect the CB to the nucleolus. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
To study CBs, coilin can be combined with GFP (Green Fluorescent Protein) to form Coilin-GFP hybrid protein. The hybrid protein can then be used to locate CBs underneath a microscope, usually near the nucleolus of the cell. Other proteins that make up the CB include snRNPs and nucleolar snoRNPs.
Coilin has been shown to interact with ataxin 1, nucleolar phosphoprotein p130, SMN, and SNRPB.
