Routes of
administration Intravenous Legal status Investigational Duration of action 24 hours | ATC code None Onset of action 10 min | |
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Synonyms PER977
N,N-[Piperazine-1,4-diylbis(propane-1,3-diyl)]bis-L-argininamide | ||
Ciraparantag (INN/USAN, or aripazine) is a drug under investigation as an antidote for a number of anticoagulant (anti-blood clotting) drugs, including factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), dabigatran, low molecular weight heparins and unfractionated heparin.
Contents
Mechanism of action
According to in vitro studies, the substance binds directly to anticoagulants via hydrogen bonds from or to various parts of the molecule:
Chemical properties
Ciraparantag consists of two L-arginine units connected with a piperazine containing linker chain.
References
Ciraparantag Wikipedia(Text) CC BY-SA