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Trade names  Diuril
MedlinePlus  a682341
ATC code  C03AA04 (WHO)
Molar mass  295.72 g/mol
AHFS/Drugs.com  Monograph
Routes of administration  Oral, IV
CAS ID  58-94-6
Trade name  Diuril
Chlorothiazide Chlorothiazide Wikipedia
Pregnancy category  US: C (Risk not ruled out)

How to pronounce chlorothiazide diuril memorizing pharmacology video flashcard

Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive.


It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

Chlorothiazide USP Monographs Chlorothiazide

It was discovered in 1957.

Hydrochlorothiazide nursing considerations side effects and mechanism of action


  • Large amount of excess fluid including:
  • Diagnosed congested heart failure
  • Peripheral edema
  • Rales / Rhonchi
  • Hypertension
  • Contraindications

  • Renal failure or insufficiency
  • Allergies to sulfa drugs
  • Side effects

  • Nausea / Vomiting
  • Headache
  • Dizziness
  • Excess urine production
  • Dehydration
  • Hypoelectrolytemia (esp. hypokalemia / hypomagnesia)
  • History

    Chlorothiazide FileChlorothiazidesvg Wikimedia Commons

    The Research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work.

    Chlorothiazide Chlorothiazide Wikipedia
    Chlorothiazide Chlorothiazide thiazide diuretic SigmaAldrich
    Chlorothiazide chlorothiazide sodium intravenous Uses Side Effects Interactions
    Chlorothiazide chlorothiazide sodium intravenous Uses Side Effects Interactions


    Chlorothiazide Wikipedia