Harman Patil (Editor)

Chlorothiazide

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Trade names
  
Diuril

MedlinePlus
  
a682341

ATC code
  
C03AA04 (WHO)

Molar mass
  
295.72 g/mol

AHFS/Drugs.com
  
Monograph

Routes of administration
  
Oral, IV

CAS ID
  
58-94-6

Trade name
  
Diuril

Chlorothiazide Chlorothiazide Wikipedia

Pregnancy category
  
US: C (Risk not ruled out)

How to pronounce chlorothiazide diuril memorizing pharmacology video flashcard


Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive.

Contents

It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

Chlorothiazide USP Monographs Chlorothiazide

It was discovered in 1957.

Hydrochlorothiazide nursing considerations side effects and mechanism of action


Indications

  • Large amount of excess fluid including:
  • Diagnosed congested heart failure
  • Peripheral edema
  • Rales / Rhonchi
  • Hypertension
  • Contraindications

  • Renal failure or insufficiency
  • Allergies to sulfa drugs
  • Side effects

  • Nausea / Vomiting
  • Headache
  • Dizziness
  • Excess urine production
  • Dehydration
  • Hypoelectrolytemia (esp. hypokalemia / hypomagnesia)
  • History

    Chlorothiazide FileChlorothiazidesvg Wikimedia Commons

    The Research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work.


    Chlorothiazide Chlorothiazide Wikipedia

    Chlorothiazide Chlorothiazide thiazide diuretic SigmaAldrich

    Chlorothiazide chlorothiazide sodium intravenous Uses Side Effects Interactions

    Chlorothiazide chlorothiazide sodium intravenous Uses Side Effects Interactions

    References

    Chlorothiazide Wikipedia