Girish Mahajan (Editor)

Cefmetazole

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Covid-19
MedlinePlus  a601206
CAS Number  56796-20-4
DrugBank  DB00274
ATC code  J01DC09 (WHO)
PubChem CID  42008
Molar mass  471.538 g/mol
Cefmetazole
AHFS/Drugs.com  International Drug Names

Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins.

Contents

Medical vocabulary what does cefmetazole mean


Adverse effects

The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram, due to inhibition of aldehyde dehydrogenase.

Spectrum of bacterial susceptibility

Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Bacteroides fragilis: 0.06 - >256 µg/ml
  • Clostridium difficile: 8 - >128 µg/ml
  • Staphylococcus aureus: 0.5 - 256 µg/ml (includes MRSA)
  • References

    Cefmetazole Wikipedia


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