Camacho was born in the village of Hagåtña, Guam to Felix Martinez Camacho (1893–1975) and Antonia Cruz Garcia. His siblings included Josephine Camacho Tanaka, John Camacho, Luis Camacho, and Eddie Camacho. From 1946 to 1949, he attended Aquinas College in Grand Rapids, Michigan. In 1952, he earned a D.D.S. degree from Marquette University in Milwaukee, Wisconsin.
In the 1974 gubernatorial election, he was defeated for reelection in a re-match senator Ricardo Bordallo won the election. An election challenge by the Bordallo/Sablan campaign went all the way to the U.S. Supreme Court. Following his unsuccessful bid for reelection as governor, Camacho resumed his career as a dentist.
At the young age of forty-four, Camacho succeeded Governor Manuel F.L. Guerrero as governor of Guam, with Kurt Moylan appointed as lieutenant governor. Camacho’s term as appointed governor lasted only eighteen months, due to the Elective Governor Act that was signed into law by the US Congress in 1968, allowing for Guam’s citizens to choose their governor. The act took effect in 1970, when Guam’s first election was held. Camacho’s term was best remembered for his Christmas 1969 visit to the troops from Guam who were fighting in Vietnam.
Camacho first selected senator G. Ricardo Salas as his running mate, but his announcement that former senator Salas takes over the running mate, as Kurt Moylan for lieutenant governor.
Camacho was a candidate in Guam's first election for governor with Kurt Moylan running for lieutenant governor. The two running mates are Republican primary, while the Democratic primary was closely between former governor Manuel F. L. Guerrero, Senator Ricardo Bordallo and attorney and former speaker Joaquin C. Arriola. After they close the primary and a contentious runoff election which is Bordallo who is defeated by Guerrero, and the general election as Camacho/Moylan defeated by Bordallo/Taitano.
Camacho and Moylan's historic inauguration was held on January 4, 1971 at the Plaza de España in Agana. He uses the resources of the government to enhance economic opportunities by granting incentives through the Guam Economics Development and offering various forms of assistance to the private sector. During his entire five and a half years in office, Camacho presided over one of the largest eras of hotel construction activities on Guam, with construction finishing or starting on the Kakue Hotel, Reef Hotel, Hilton Hotel, Okura Hotel, Fujita Tumon Beach, Continental Travelodge, and Guam Dai Ichi Hotel.
Camacho also initiated massive road projects that were continued by his successors, including the widening of Marine Drive (now Marine Corps Drive) from Hospital Road north to Route 16 in Harmon, and the reconstruction of other major highways in the villages of Agat, Dededo and Tamuning, among others.
He is also credited with enticing many educated Chamorros back to Guam, to reverse what was seen as a “brain drain” at the time, including Tony Palomo, Greg Sanchez, Mary Sanchez, Tony Unpingco, Dr. Pedro Sanchez, Dr. Katherine Aguon, Juan C. Tenorio, Bert Unpingco, Ben Perez, Eddie Duenas, Joseph F. Ada and Frank Blas. Many of them took jobs with the government of Guam as administrators and later became senators. Camacho also kept on other able administrators even if they were not of his party affiliation which served to stabilize the government.
As a team, Camacho and Moylan worked to develop economic opportunity by creating incentives to attract business and encourage local participation in business. At the time Guam elected its first governor the federal government still had control over much of the island’s utilities and roads. They struggled to work toward gaining more self-government and self-determination.
Camacho was married to the former Lourdes Duenas Perez, and had seven children, including former Governor of Guam, Felix Perez Camacho, Carlos, Thomas, Ricardo, Francis, Victor, and his only daughter Mary Camacho Torres is now a senator from the Guam Legislature, she is married to Supreme Court of Guam Chief Justice Robert J. Torres, Jr.. Originally appointed in 1969, he became Guam's first elected governor the following year and served in that capacity until August 1975.
Following his defeat, Camacho return to his career as a dentist, continuing in private practice until his death on December 6, 1979 four years later, at the age of 55.