EC number 3.1.1.1 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9016-18-6 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a carboxylesterase or carboxylic-ester hydrolase (EC 3.1.1.1) is an enzyme that catalyzes a chemical reaction of the form
Contents
a carboxylic ester + H2OThus, the two substrates of this enzyme are carboxylic ester and H2O, whereas its two products are alcohol and carboxylate.
Most enzymes from this group are serine hydrolases belonging to the superfamily of proteins with alpha/beta hydrolase fold. Some exceptions include an esterase with beta-lactamase like structure (PDB: 1ci8).
Carboxylesterases are widely distributed in nature, and are common in mammalian liver. Many participate in phase I metabolism of xenobiotics such as toxins or drugs; the resulting carboxylates are then conjugated by other enzymes to increase solubility and eventually excreted.
The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases.
Examples
The last enzyme also participates in alkaloid biosynthesis.
Genes
Humans genes that encode carboxylesterase enzymes include:
An approved nomenclature has been established for the five mammalian carboxylesterase gene families.