Reid was born on November 23, 1991 in Bronx, New York. He is the son of Courton, the Bishop of City of Faith Church of God in the Bronx, a school principal, and psychologist, and Claudette Reid, also a minister, hematologist, and licensed educator. Reid has two older brothers Caryl and CaVar.
Reid attended Mount Saint Michael Academy in The Bronx, New York. Named two-time team captain, he earned all-league honors twice and all-city and all-state honors as a senior. He was the winner of the school's Monsignor Matthew Peters student-athlete award, and was a member of the National Honor Society and the National Society of High School Scholars.
He was considered a two-star recruit by Rivals.com.
His academic excellence led him to Princeton University, where he played for the Tigers from 2009 to 2013. In 2009, recorded 34 tackles, most among all Princeton freshmen, and added 4.5 tackles for loss, four pass breakups and a sack. In 2010, Reid played in only one game before suffering a season-ending injury. In 2011, he earned first-team All-Ivy League honors after leading all Ivy League linemen with 68 tackles, including 29 solo stops. He led Princeton in tackles for loss (16), sacks (eight), pass breakups (three), quarterback hurries (three) and blocked kicks (three). In 2012, he earned third-team FCS All-American honors by the Associated Press, after recording 40 tackles, including 9.5 for losses, 5.5 sacks and three blocked kicks. He also earned unanimous first-team All-Ivy League honors on the defensive line. In 2013, he was named a finalist for the Ivy League Defensive Player of the Year honors. He earned his third straight first-team All-Ivy League honor, only the fourth player in Princeton history to earn the honor three times. He recorded 26 tackles, including 11 for loss, 6.5 sacks, one interception and one blocked kick.
Reid was drafted by the Detroit Lions in the fifth round (158th overall) of the 2014 NFL Draft. In 2015 against the Seattle Seahawks, Reid returned a Russell Wilson fumble for a touchdown, cutting the score to 13-10. However, the Lions would lose on a controversial call. On September 3, 2016, Reid was waived by the Lions.
The San Diego Chargers claimed Reid off waivers on September 4, 2016. In Week 7 against the Atlanta Falcons, Reid injured his ACL and was placed on injured reserve on October 25, 2016.
On September 2, 2017, Reid was waived by the Chargers.