Camille Prats is the second child of Daniel Rafael and Alma (née Quiambao) Prats, the latter of whom is from Pampanga. She is also the niece of former actress Mia Prats. She has a sister and three brothers, one of whom is fellow actor John Prats.
On September 23, 2011, her first husband, Anthony Linsangan, died of nasopharyngeal carcinoma at the age of 31. On January 7, 2017, Prats married businessman John Yambao in Batangas. On February 1, 2017, she confirmed in an interview that she is expecting her second child.
Camille Prats's first foray into show business came in 1990 when she was a contestant in "Little Miss Philippines", a popular segment of the variety show Eat Bulaga. This led to her regular appearances in ABS-CBN's children's program Ang TV.
In 1995, Camille Prats catapulted into fame when she starred in the movie Sarah... Ang Munting Prinsesa, a Philippine adaptation of the anime Princess Sarah, which was in turn based on Frances Hodgson Burnett children's novel A Little Princess.
As Camille Prats grew up, she appeared in sitcoms and teen-oriented dramas. But in 2006, she decided to shed her "Princess Sarah" image by posing for the Philippine edition of FHM Magazine.
Camille Prats is currently seen in GMA Network television programs such as the weekly variety show SOP Gigsters, the telefantasya Super Twins and the sitcom Ganda ng Lola Ko (aired by Quality TeleVision, a subsidiary of GMA Network). She was also one of Richard Gutierrez's leading ladies in Captain Barbell. Camille Prats is now managed by ALV, and is now a contract artist of GMA Network.
Like her brother John Prats, young TV actress Camille Prats decided to go to the United States in September 2007 to finish her studies.
Anthony C. Linsangan, from AMA Makati and founder of Wheels Auto Performance, is the actual father of Camille's baby. Prats confirmed her civil marriage with Anthony Linsangan on January 5, 2008 in Los Angeles, California at The Albertson Wedding Chapel.
On January 24, 2008, Prats gave birth to her first child, Nathaniel Caesar P. Linsangan.
In 2009 she was allowed to be part of the horror film T2 distributed by Star Cinema under ABS-CBN Film and also recently invited in Kapamilya Deal or No Deal also seen on ABS-CBN. But she confirmed via PEP.com that she will remain a GMA contract actress.
Camille Prats also appeared in her first villainess role in Bantatay Prats is now currently starring in the heavy drama aired on GMA Network titled Munting Heredera co-starring with Gloria Romero which became the most watched TV drama in primetime.