Calhoun is a surname of Scottish and Irish origin. It is a variant of the surname Colquhoun. Notable people with the surname include:
Alice Calhoun (1900–1966), American silent film actressAnn Marie Calhoun, American violinistBootsie Calhoun, American politicianCharles Calhoun, Jr., American politician and juristCraig Calhoun, American sociologistChad Calhoun, a pseudonym of Ron Goulart, writerDon Calhoun, former professional American football running backFloride Calhoun, wife of John C. Calhoun, Second Lady of the United StatesGeorge Whitney Calhoun, co-founder of the Green Bay Packers NFL football teamJames Calhoun (soldier), American soldier, killed at the Battle of Little BighornJames S. Calhoun, Georgia Politician, Army Colonel, Federal Indian Agent, and Territorial Governor of New MexicoJermie Calhoun, running back for the Oklahoma SoonersJim Calhoun, head coach of the University of Connecticut men's basketball teamJohn B. Calhoun, American EthologistJohn C. Calhoun, United States politician and 7th Vice PresidentJohn A. Calhoun, American diplomatKole Calhoun, American Major League Baseball playerKutt Calhoun ("Melvin Calhoun"), musicianMeredith Calhoun, planter and newspaper publisherMilburn E. Calhoun, physician and publisherMilo Calhoun, Jamaican boxer of the 1960s and '70sMonica Calhoun, actressRiemer Calhoun, American politicianRory Calhoun, actorWill Calhoun, musicianWilliam Calhoun ("Haystack"), professional wrestlerWilliam Lowndes Calhoun, mayor of Atlanta, Georgia in 1879