Calhoun is a surname of Scottish and Irish origin. It is a variant of the surname Colquhoun. Notable people with the surname include:
Alice Calhoun (1900–1966), American silent film actress
Ann Marie Calhoun, American violinist
Bootsie Calhoun, American politician
Charles Calhoun, Jr., American politician and jurist
Craig Calhoun, American sociologist
Chad Calhoun, a pseudonym of Ron Goulart, writer
Don Calhoun, former professional American football running back
Floride Calhoun, wife of John C. Calhoun, Second Lady of the United States
George Whitney Calhoun, co-founder of the Green Bay Packers NFL football team
James Calhoun (soldier), American soldier, killed at the Battle of Little Bighorn
James S. Calhoun, Georgia Politician, Army Colonel, Federal Indian Agent, and Territorial Governor of New Mexico
Jermie Calhoun, running back for the Oklahoma Sooners
Jim Calhoun, head coach of the University of Connecticut men's basketball team
John B. Calhoun, American Ethologist
John C. Calhoun, United States politician and 7th Vice President
John A. Calhoun, American diplomat
Kole Calhoun, American Major League Baseball player
Kutt Calhoun ("Melvin Calhoun"), musician
Meredith Calhoun, planter and newspaper publisher
Milburn E. Calhoun, physician and publisher
Milo Calhoun, Jamaican boxer of the 1960s and '70s
Monica Calhoun, actress
Riemer Calhoun, American politician
Rory Calhoun, actor
Will Calhoun, musician
William Calhoun ("Haystack"), professional wrestler
William Lowndes Calhoun, mayor of Atlanta, Georgia in 1879
