Aliases CRKL Ensembl ENSG00000099942 | Entrez 1399 | |
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External IDs MGI: 104686 HomoloGene: 38021 GeneCards: CRKL | ||
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
Contents
Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.
CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.
Interactions
CRKL has been shown to interact with:
References
CRKL Wikipedia(Text) CC BY-SA