Kalpana Kalpana (Editor)

COUP TFII

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Species
  
Entrez
  
7026

Human
  
Ensembl
  
ENSG00000185551

COUP-TFII jmeendocrinologyjournalsorgcontent493R135F

Aliases
  
NR2F2, ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2, COUP-TFII, nuclear receptor subfamily 2 group F member 2

External IDs
  
MGI: 1352452 HomoloGene: 7628 GeneCards: NR2F2

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene. The COUP acronym stands for chicken ovalbumin upstream promoter.

Contents

Function

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity. COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.

Interactions

COUP-TFII has been shown to interact with:

  • HDAC1
  • Lck
  • V-erbA-related gene.
  • Nucleolin
  • References

    COUP-TFII Wikipedia


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